Publication Name	World Journal of Orthopedics
Manuscript ID	111046
Country	China

Category	Orthopedics
Manuscript Type	Letter to the Editor
Article Title	Biodegradable materials: Applications and advances of magnesium alloys in bone defects
Manuscript Source	Invited Manuscript
All Author List	Jing-Shun Lu, Zeng-Gao Han, Chen-Yu Song, Min Yang, Yuan-Sheng Huang and Kai-Yang Wang
Funding Agency and Grant Number
Corresponding Author	Kai-Yang Wang, MD, Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, China. ortho_wang@163.com
Key Words	Bone defects; Biodegradable synthetic materials; Magnesium alloys; Multiple mechanisms; Biocompatibility
Core Tip	Degradable magnesium (Mg) alloys have been extensively utilized in the treatment of bone defects owing to their superior mechanical properties, excellent biocompatibility, and potent osteogenic capabilities. Mg alloys enhance bone tissue regeneration via multiple mechanisms, including the bone-nerve circuit, promotion of vascular regeneration, modulation of the immune microenvironment, and upregulation of osteogenic signaling pathways. Additionally, Mg alloys have been engineered into diverse application forms, such as Mg-infused metallic scaffolds and Mg-based bone regeneration membranes. The therapeutic potential of Mg alloys for addressing bone defects warrants further investigation in future studies.
Citation	Lu JS, Han ZG, Song CY, Yang M, Huang YS, Wang KY. Biodegradable materials: Applications and advances of magnesium alloys in bone defects. World J Orthop 2025; In press

Received	2025-06-24 06:57
Peer-Review Started	2025-06-24 06:57
To Make the First Decision
Return for Revision	2025-07-14 07:04
Revised	2025-07-28 01:53
Second Decision	2025-11-13 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 05:59
Articles in Press	2025-11-13 05:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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