Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	111082
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Intestinal-related substances in obesity regulation: A comprehensive review
Manuscript Source	Invited Manuscript
All Author List	Shuai-Yan Wang, Meng-Zhe Zhang, Zi-Ming Chen, Zi-Mu Li, Cong-Yi Xie, Guan-Hu Yang, Bin Xu and Tian-Cheng Xu
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation, Youth Science Fund Project 82305376 the Youth Talent Support Project of the China Acupuncture and Moxibustion Association 2024-2026ZGZJXH-QNRC005 the 2024 Jiangsu Province Youth Science and Technology Talent Support Project JSTJ-2024-380 2025 Jiangsu Provincial Science and Technology Think Tank Program Project JSKX0125035
Corresponding Author	Tian-Cheng Xu, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn
Key Words	Obesity; Gut hormones; Microbial metabolites; Indole-3-propionic acid; Gut-brain axis
Core Tip	Gut hormones, microbial metabolites, and neurotransmitters such as 5-hydroxytryptamine (serotonin), short-chain fatty acids, and indolepropionic acid play crucial roles in regulating metabolism and obesity. Emerging therapies like glucagon-like peptide-1 receptor agonists and gut microbiota modulation show promise in addressing these factors. Future research should focus on personalized, multi-target approaches for effective obesity management, optimizing treatments, and understanding the diverse impacts of gut-derived substances on metabolic healt
Citation	Wang SY, Zhang MZ, Chen ZM, Li ZM, Xie CY, Yang GH, Xu B, Xu TC. Intestinal-related substances in obesity regulation: A comprehensive review. World J Gastrointest Pharmacol Ther 2025; In press

Received	2025-06-23 09:52
Peer-Review Started	2025-06-23 09:54
To Make the First Decision
Return for Revision	2025-08-07 01:24
Revised	2025-08-20 16:55
Second Decision	2025-11-17 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-17 09:17
Articles in Press	2025-11-17 09:17
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ISSN	2150-5349 (online)
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