Publication Name	World Journal of Clinical Oncology
Manuscript ID	111086
Country	India

Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Provoking myofibroblast death: Strategies to resolve fibrosis and remodel tumor microenvironment
Manuscript Source	Invited Manuscript
All Author List	Thangavelu Shalini and Ganapasam Sudhandiran
Funding Agency and Grant Number
Corresponding Author	Ganapasam Sudhandiran, Associate Professor, PhD, Professor, Cell Biology Laboratory, Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamil Nādu, India. sudhandiran@yahoo.com
Key Words	Myofibroblast apoptosis; Fibrosis resolution; Tumor microenvironment; Extracellular matrix remodeling; Fibroblast activation; Cancer-associated fibroblasts; Mechanotransduction in fibrosis
Core Tip	Myofibroblasts are contractile cells that play a central role in both fibrosis and tumor progression due to their involvement in excessive extracellular matrix deposition and tissue stiffening. This article highlights emerging strategies to selectively inactivate or induce myofibroblast death, aiming to resolve fibrosis and remodel the tumor microenvironment. By exploring diverse disease models of fibrosis and cancer, this review underscores the therapeutic potential of targeting myofibroblasts to halt chronic tissue damage and improve cancer treatment outcomes.
Citation	Shalini T, Sudhandiran G. Provoking myofibroblast death: Strategies to resolve fibrosis and remodel tumor microenvironment. World J Clin Oncol 2025; In press

Received	2025-06-23 01:13
Peer-Review Started	2025-06-23 01:14
To Make the First Decision
Return for Revision	2025-07-15 09:55
Revised	2025-07-28 11:41
Second Decision	2025-11-13 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 10:47
Articles in Press	2025-11-13 10:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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