Publication Name	World Journal of Transplantation
Manuscript ID	111122
Country	India

Category	Anesthesiology
Manuscript Type	Minireviews
Article Title	Perioperative management of pediatric patients with inborn errors of metabolism during liver transplantation
Manuscript Source	Invited Manuscript
All Author List	Susan Paulin, Akila Rajakumar, Jagadeesh Menon, Naresh Shanmugam and Mohamed Rela
Funding Agency and Grant Number
Corresponding Author	Akila Rajakumar, FRCA, Head, Department of Liver Transplant Anaesthesia and Intensive Care, Institute of Liver Disease and Transplantation, Rela Institute, 7, CLC Works Road, Chromepet, Chennai 600044, Tamil Nadu, India. drakila.rajakumar@gmail.com
Key Words	Inborn errors of metabolism; Anaesthesia for paediatric liver transplantation; Metabolic crisis; Hyperammonemia in paediatric liver transplantation; Perioperative care in metabolic liver diseases
Core Tip	Most metabolic disorders are liver-based, and liver transplantation (LT) has emerged as an effective cure for a variety of inherited metabolic disorders in the pediatric population. LT has been shown to offer a cure, deter disease progression and provide symptomatic improvement in patients with inherited metabolic disorders. Perioperative management of these children presenting for LT with inborn errors of metabolism (IEM) requires disease specific and patient specific strategies in all aspects right from preoperative assessment, intraoperative and postoperative management compared to those presenting with other indications. Knowledge about the distribution of deficient enzymes, the percentage of enzymes replaced by LT, and the extent of extrahepatic involvement helps anticipate and manage complications in the perioperative period.
Citation	Paulin S, Rajakumar A, Menon J, Shanmugam N, Rela M. Perioperative management of pediatric patients with inborn errors of metabolism during liver transplantation. World J Transplant 2025; In press

Received	2025-06-27 01:09
Peer-Review Started	2025-06-27 01:09
To Make the First Decision
Return for Revision	2025-07-17 10:22
Revised	2025-07-25 08:18
Second Decision	2025-11-05 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-05 08:51
Articles in Press	2025-11-05 08:51
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Typeset the Manuscript

ISSN	2220-3230 (online)
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