Publication Name	World Journal of Clinical Cases
Manuscript ID	111134
Country	Italy

Category	Ophthalmology
Manuscript Type	Review
Article Title	Beyond the optic disc: Investigating gender-based differences in optic neuritis
Manuscript Source	Invited Manuscript
All Author List	Marco Zeppieri, Simonetta Gaia Nicolosi, Fabiana D’Esposito, Mutali Musa, Alessandro Avitabile, Caterina Gagliano, Marco Battista, Piero Barboni and Matteo Capobianco
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, MD, PhD, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Optic neuritis; Gender differences; Neuromyelitis optica spectrum disorder; Myelin oligodendrocyte glycoprotein antibody disease; Optic nerve
Core Tip	Optic neuritis (ON) is affected by sex at all levels, from molecular biology to clinical outcomes. Women are considerably more predisposed to developing ON, particularly in aquaporin 4 IgG positive neuromyelitis optica spectrum disorder. Men frequently experience more severe long-term neuroaxonal damage. The interaction of genetic, hormonal, metabolic, and behavioral variables highlights the necessity for sex-specific strategies in the diagnosis, treatment, and research of ON. Comprehending these distinctions is crucial for enhancing individualized treatment in ON across various demyelinating conditions.
Citation	Zeppieri M, Nicolosi SG, D’Esposito F, Musa M, Avitabile A, Gagliano C, Battista M, Barboni P, Capobianco M. Beyond the optic disc: Investigating gender-based differences in optic neuritis. World J Clin Cases 2025; In press

Received	2025-06-24 08:36
Peer-Review Started	2025-06-24 08:37
To Make the First Decision
Return for Revision	2025-06-30 06:42
Revised	2025-07-07 11:19
Second Decision	2025-10-11 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-11 08:14
Articles in Press	2025-10-11 08:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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