Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	111144
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Sonazoid-contrast-enhanced ultrasound for the histological diagnosis of hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Ruo-Bing Liu, Jun-Yi Xin, Zhe Huang and Kai-Yan Li
Funding Agency and Grant Number
Corresponding Author	Kai-Yan Li, Chief Physician, PhD, Professor, Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Qiaokou District, Wuhan 430030, Hubei Province, China. liky20006@126.com
Key Words	Contrast-enhanced ultrasound; Hepatocellular carcinoma; Quantitative parameters; Kupffer phase; Pathological differentiation
Core Tip	This study used quantitative parameters and imaging characteristics from Sonazoid-contrast-enhanced ultrasound using perfluorobutane microspheres to evaluate the histological differentiation of hepatocellular carcinoma (HCC). Both univariate and multivariate analyses indicated that Kupffer phase parameters, particularly the intensity ratio (IR), outperformed conventional clinical markers. IR proved to be a valuable, non-invasive predictor of tumor differentiation, supporting more informed preoperative decision-making in HCC management. It is simple to calculate, relatively unaffected by variations in hepatic perfusion or fibrosis, and well-suited for routine clinical application. Receiver operating characteristic analysis identified an optimal cut-off value of 1.215 for IR.
Citation	Liu RB, Xin JY, Huang Z, Li KY. Sonazoid-contrast-enhanced ultrasound for the histological diagnosis of hepatocellular carcinoma. World J Gastrointest Oncol 2025; In press

Received	2025-07-01 06:00
Peer-Review Started	2025-07-01 06:00
To Make the First Decision
Return for Revision	2025-07-14 03:46
Revised	2025-07-25 13:22
Second Decision	2025-11-17 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-18 00:06
Articles in Press	2025-11-18 00:06
Publication Fee Transferred	2025-07-29 13:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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