Publication Name	World Journal of Hepatology
Manuscript ID	111153
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Histone lactylation: A key epigenetic modulator in the pathogenesis of metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis
Manuscript Source	Invited Manuscript
All Author List	Mable Misha Singh, Arunim Shah, Sangam Rajak, Chandra Prakash Chaturvedi and Rohit A Sinha
Funding Agency and Grant Number	Funding Agency Grant Number Science and Engineering Research Board CRG/2022/002149 Indian Council of Medical Research ICMR/02/833/IGP-2024, R.12016/12/2023-HR
Corresponding Author	Rohit A Sinha, Associate Professor, Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow 226014, Uttar Pradesh, India. anthony.rohit@gmail.com
Key Words	Histone lactylation; Metabolic dysfunction-associated steatohepatitis; Alcoholic steatohepatitis; Epigenetics; Lactate
Core Tip	This review article describes a biological process called histone lactylation and its role in liver diseases. Histone lactylation is a metabolically aligned epigenetic modification on histones which can regulate hepatic gene expression. Increased lactate levels in metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis may induce histone lactylation of key genes involved in hepatic lipogenesis, inflammation and fibrosis. Consequently, pharmacological modulation of histone lactylation may open a new therapeutic option to counter metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis progression.
Citation	Singh MM, Shah A, Rajak S, Chaturvedi CP, Sinha RA. Histone lactylation: A key epigenetic modulator in the pathogenesis of metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis. World J Hepatol 2025; In press

Received	2025-06-24 08:40
Peer-Review Started	2025-06-24 08:41
To Make the First Decision
Return for Revision	2025-07-31 01:15
Revised	2025-08-06 09:48
Second Decision	2025-11-06 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-06 11:40
Articles in Press	2025-11-06 11:40
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ISSN	1948-5182 (online)
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