Publication Name	World Journal of Diabetes
Manuscript ID	111165
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Endothelial cell-derived exosomes inhibit high glucose-induced osteoblast ferroptosis by activating microRNA-335-3p/prostaglandin endoperoxide synthase 2
Manuscript Source	Unsolicited Manuscript
All Author List	Chen Shao, Li-Jian Zhang, Yi-Lin Song, Yan-Qiu Wang, Xiu-Jing Zha, Juan Li, Cheng-Song Ye, Ling-Ling Chen, Ming-Wei Chen and Guo-Xi Jin
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Projects of Bengbu Medical College 2022byzd088 Anhui Province Higher Education Scientific Research Project 2024AH051285 Anhui Provincial Department of Education Humanities and Social Science Key Project 2023AH051900 Key Research and Development Program Projects of Anhui Province 202204295107020049
Corresponding Author	Guo-Xi Jin, Chief Physician, PhD, Professor, Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Bengbu 233004, Anhui Province, China. jinguoxi@bbmu.edu.cn
Key Words	Type 2 diabetes; Osteoporosis; Exosomes; Ferroptosis; Oxidative stress
Core Tip	Endothelial cell-derived exosomes demonstrate inherent bone-targeting properties, their role in counteracting high glucose-induced osteoblast ferroptosis remains unexplored. This study reveals that endothelial cell-derived exosomes protect osteoblasts from high glucose-induced ferroptosis by regulating microRNA-335-3p/prostaglandin endoperoxide synthase 2. The diagnostic potential of serum microRNA-335-3p for diabetic osteoporosis was demonstrated, warranting further validation with an expanded sample size.
Citation	Shao C, Zhang LJ, Song YL, Wang YQ, Zha XJ, Li J, Ye CS, Chen LL, Chen MW, Jin GX. Endothelial cell-derived exosomes inhibit high glucose-induced osteoblast ferroptosis by activating microRNA-335-3p/prostaglandin endoperoxide synthase 2. World J Diabetes 2025; In press

Received	2025-06-25 01:53
Peer-Review Started	2025-06-25 09:19
First Decision by Editorial Office Director	2025-07-11 07:44
Return for Revision	2025-07-11 07:44
Revised	2025-07-21 14:56
Publication Fee Transferred	2025-07-23 09:10
Second Decision by Editor	2025-10-15 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-02 07:26
Articles in Press	2025-12-02 07:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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