Publication Name	World Journal of Clinical Oncology
Manuscript ID	111175
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Relevance and application of sirtuin 3-activated mitophagy in gastric cancer treatment
Manuscript Source	Invited Manuscript
All Author List	Hao-Yu Zhao, Chu-Ying Yu, Xin-Tong Ye, Su-Ting Qian, Ye Huang and Qing-Sheng Liu
Funding Agency and Grant Number
Corresponding Author	Qing-Sheng Liu, Chief Physician, Department of Gastroenterology, Third People's Hospital of Hangzhou, No. 453 Stadium Road, Hangzhou 310009, Zhejiang Province, China. 7394822@qq.com
Key Words	Sirtuin 3; Gastric cancer; Mitochondrial function; Mitophagy; Oxidative stress; Antitumor
Core Tip	Sirtuin 3 (SIRT3), a mitochondrial NAD+-dependent deacetylase, regulates mitophagy via protein acetylation and signaling pathways. Downregulated in gastric cancer (GC), its low expression links to poor prognosis, deeper invasion, and reduced differentiation. SIRT3 enhances mitophagy to alleviate oxidative stress, correct mitochondrial dysfunction, and inhibit GC. Preclinical studies show it synergizes with therapies, boosting efficacy and reducing toxicity. This mini-review covers its mechanisms, therapeutic potential, and prospects for activator/delivery system development.
Citation	Zhao HY, Yu CY, Ye XT, Qian ST, Huang Y, Liu QS. Relevance and application of sirtuin 3-activated mitophagy in gastric cancer treatment. World J Clin Oncol 2025; In press

Received	2025-06-26 04:18
Peer-Review Started	2025-06-26 04:18
To Make the First Decision
Return for Revision	2025-08-09 13:22
Revised	2025-08-14 12:07
Second Decision	2025-11-12 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 03:40
Articles in Press	2025-11-13 03:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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