Publication Name	World Journal of Hepatology
Manuscript ID	111211
Country	Singapore

Category	Pediatrics
Manuscript Type	Minireviews
Article Title	Fighting the epidemic of pediatric metabolic dysfunction-associated steatotic liver disease: Role of non-invasive diagnostics and early pharmacological intervention
Manuscript Source	Invited Manuscript
All Author List	Nicholas Beng-Hui Ng, Andrew Anjian SNG and James Guoxian Huang
Funding Agency and Grant Number
Corresponding Author	James Guoxian Huang, Assistant Professor, Khoo Teck Puat - National University Children's Medical Institute, Department of Paediatrics, National University Health System, 1E Kent Ridge Road NUHS Tower Block Level 12, Singapore 119228, Singapore. paehgj@nus.edu.sg
Key Words	Pediatric metabolic dysfunction-associated steatotic liver disease; Glucagon-like peptide 1 receptor agonists; Vibration-controlled transient elastography; Resmetirom; Pediatric obesity
Core Tip	The escalating prevalence of pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) mirrors the rise in pediatric obesity. The advent of non-invasive diagnostics may allow for earlier recognition of liver fibrosis, and may prioritize the need for early pharmacological therapy. We propose an updated diagnostic and monitoring algorithm incorporating recent multi-societal statements in pediatric MASLD. The increased use of weight-loss pharmacotherapy such as glucagon-like peptide 1 receptor agonists in adolescent patients has shown efficacy in inducing weight loss, which may have potential in halting MASLD progression if instituted early in the disease course.
Citation	Ng NBH, Sng AA, Huang JG. Fighting the epidemic of pediatric metabolic dysfunction-associated steatotic liver disease: Role of non-invasive diagnostics and early pharmacological intervention. World J Hepatol 2025; In press

Received	2025-06-26 08:22
Peer-Review Started	2025-06-26 08:26
First Decision by Editorial Office Director	2025-07-21 09:00
Return for Revision	2025-07-21 13:37
Revised	2025-09-02 09:06
Publication Fee Transferred
Second Decision by Editor	2025-12-01 03:10
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-02 06:09
Articles in Press	2025-12-02 06:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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