Publication Name	World Journal of Clinical Cases
Manuscript ID	111246
Country	Croatia

Category	Hematology
Manuscript Type	Minireviews
Article Title	Unfolding the enigma of familial Hodgkin lymphoma: Current insights
Manuscript Source	Invited Manuscript
All Author List	Jelena Roganovic, Nusa Matijasic Stjepovic and Ana Dordevic
Funding Agency and Grant Number
Corresponding Author	Jelena Roganovic, MD, PhD, Tenured Professor, Department for Pediatric Oncology and Hematology, Children's Hospital Zagreb, Klaiceva 16, Zagreb 10000, Grad, Croatia. jelena.roganovic02@gmail.com
Key Words	Hodgkin lymphoma; Familial Hodgkin lymphoma; Genetic analysis; Whole genome sequencing; Pathogenic variants
Core Tip	Hodgkin lymphoma (HL), although rare, is one of the most common pediatric malignancies. Familial clustering points to genetic susceptibility, especially in young-onset cases. Recently, whole-genome sequencing studies of affected families have identified several predisposing genetic variants, contributing to unraveling the complex etiopathogenesis of HL. New insights into tumor biology and the identification of germline mutations may facilitate genetic counselling, raising awareness among first-degree relatives of HL patients about potential symptoms and leading to earlier diagnosis and better outcomes. Emphasizing that the hereditary risk of HL remains low can provide significant psychological relief for affected families.
Citation	Roganovic J, Matijasic Stjepovic N, Dordevic A. Unfolding the enigma of familial Hodgkin lymphoma: Current insights. World J Clin Cases 2025; In press

Received	2025-06-30 12:54
Peer-Review Started	2025-06-30 12:54
First Decision by Editorial Office Director	2025-07-19 01:50
Return for Revision	2025-07-19 01:50
Revised	2025-08-01 12:05
Publication Fee Transferred
Second Decision by Editor	2025-12-22 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-22 08:57
Articles in Press	2025-12-22 08:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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