Publication Name	World Journal of Stem Cells
Manuscript ID	111348
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Breast cancer stem cell activity driven by ME18D gene expression in the tumor microenvironment
Manuscript Source	Unsolicited Manuscript
All Author List	De-Yang Guo, Zhang-Yi Liu and Qian-Chuan Yi
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Yongchuan District 2023yc-jckx20021
Corresponding Author	Qian-Chuan Yi, Department of General Surgery, University-Town Hospital of Chongqing Medical University, No. 55 Daxuecheng Middle Road, Shapingba District, Chongqing 401331, China. anyway173@163.com
Key Words	Breast cancer stem cells; Surface markers; Transcriptomics; Least absolute shrinkage and selection operator regression; Prognostic model
Core Tip	This study integrates flow cytometry, transcriptomics, least absolute shrinkage and selection operator modeling, single-cell and spatial transcriptomics to comprehensively characterize breast cancer stem cells. CD105 was identified as a key surface marker, and a prognostic gene signature including MED18 was developed. MED18 showed strong correlations with tumor, immune, and stromal cells, suggesting a central role in breast cancer stem cell regulation and microenvironment interaction. These findings offer novel insights into tumor heterogeneity and provide potential biomarkers and therapeutic targets for precision treatment in breast cancer.
Citation	Guo DY, Liu ZY, Yi QC. Breast cancer stem cell activity driven by ME18D gene expression in the tumor microenvironment. World J Stem Cells 2025; In press

Received	2025-07-01 09:18
Peer-Review Started	2025-07-01 09:18
To Make the First Decision
Return for Revision	2025-07-24 08:05
Revised	2025-08-07 15:09
Second Decision	2025-11-18 01:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-18 02:04
Articles in Press	2025-11-18 02:04
Publication Fee Transferred	2025-08-15 01:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com