Publication Name	World Journal of Gastroenterology
Manuscript ID	111358
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach
Manuscript Source	Invited Manuscript
All Author List	Wei-Wei Dong, Tao Liu, Li-Xia He and Wen-Ting He
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Program of Gansu Province No. 23JRRA1015
Corresponding Author	Wen-Ting He, The Second Hospital and Clinical Medical School, Lanzhou University, No. 82 Cuiyingmen, Chengguan District, Lanzhou 730030, Gansu Province, China. hewt@lzu.edu.cn
Key Words	Inflammatory bowel disease; Pyroptosis; Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3; Caspase-1; Gasdermin D; Pyroptosis inhibitors
Core Tip	This review examines pyroptosis as a pivotal mechanism in inflammatory bowel disease (IBD) pathogenesis, driving inflammation and tissue damage. It evaluates therapeutic strategies targeting pyroptosis pathways, emphasizing their potential to modulate disease progression. Key challenges including drug specificity, delivery, and safety are analyzed, alongside opportunities for combination therapies. The discussion highlights the need for precision approaches and improved translational models to advance pyroptosis-targeted treatments for IBD. Future directions focus on overcoming current limitations to optimize clinical outcomes.
Citation	Dong WW, Liu T, He LX, He WT. Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach. World J Gastroenterol 2025; In press

Received	2025-06-30 08:02
Peer-Review Started	2025-06-30 08:02
To Make the First Decision
Return for Revision	2025-09-03 06:50
Revised	2025-09-14 12:57
Second Decision	2025-10-21 02:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-21 06:25
Articles in Press	2025-10-21 06:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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