Publication Name	World Journal of Hepatology
Manuscript ID	111418
Country	Romania

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Retrospective Cohort Study
Article Title	Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease
Manuscript Source	Invited Manuscript
All Author List	Bogdan-Ioan Stanciu, Marcela Iojiban, Andreea Morariu-Barb, Cosmin Caraiani, Bogdan Procopet, Horia Stefanescu and Monica Lupsor-Platon
Funding Agency and Grant Number
Corresponding Author	Monica Lupsor-Platon, MD, PhD, Professor, Department of Radiology and Medical Imaging, “Iuliu Hațieganu” University of Medicine and Pharmacy, Str. Victor Babeş No. 8, Cluj-Napoca 400012, Cluj, Romania. monica.lupsor@umfcluj.ro
Key Words	Advanced chronic liver disease; Magnetic resonance imaging; Gadoxetate disodium; Hepatic enhancement; Signal intensity; Prognostic biomarkers; Liver function assessment
Core Tip	This study investigated whether quantitative gadoxetate-enhanced magnetic resonance imaging can enhance prognostic assessment in patients with advanced chronic liver disease. Among 100 patients, hepatic enhancement (HE) and signal intensity were measured segmentally and globally. Global HE correlated strongly with Functional Liver Imaging Score, clinico-biological scores (Child-Pugh, Model of End-stage Liver Disease 3.0, Albumin-Bilirubin, and Fibrosis-4), liver stiffness, and portal pressure. Notably, lower HE independently predicted hepatic decompensation and mortality, demonstrating good diagnostic accuracy. These results suggest that HE provides an objective and reproducible biomarker that may complement conventional scoring systems, facilitating the earlier identification of high-risk patients and supporting personalized management strategies in clinical hepatology.
Citation	Stanciu BI, Iojiban M, Morariu-Barb A, Caraiani C, Procopet B, Stefanescu H, Lupsor-Platon M. Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease. World J Hepatol 2025; In press

Received	2025-07-01 03:18
Peer-Review Started	2025-07-01 03:19
To Make the First Decision
Return for Revision	2025-08-17 13:03
Revised	2025-09-01 10:16
Second Decision	2025-11-05 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-05 05:48
Articles in Press	2025-11-05 05:48
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Edit the Manuscript by Language Editor
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ISSN	1948-5182 (online)
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