Publication Name	World Journal of Clinical Oncology
Manuscript ID	111426
Country	Egypt

Category	Pathology
Manuscript Type	Retrospective Study
Article Title	Evaluating murine double minute 2 status as a stratification tool for risk-adapted management in plasma cell neoplasms
Manuscript Source	Invited Manuscript
All Author List	Noura A A Ebrahim, Habiba Elfandy, Aya Arafat, Amira Diyaa Darwish and Mahitab Ibrahim Eltohamy
Funding Agency and Grant Number
Corresponding Author	Noura A A Ebrahim, Oncologic Pathology, National Cancer Institute, Cairo University, 1st Kasr Alainy street, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com
Key Words	Multiple myeloma; Murine double minute 2; Plasma cell neoplasms; Immunohistochemistry; Prognostic biomarker; Relapse-free survival; p53 pathway; Risk stratification; CD45; Epithelial membrane antigen
Core Tip	This research explores the prognostic significance of murine double minute 2 (MDM2) expression in plasma cell neoplasms, with particular attention to plasmacytomas. The findings reveal a distinct subset of patients with MDM2 positivity who demonstrate poorer early treatment responses and markedly shorter relapse-free survival intervals. Incorporating MDM2 expression into contemporary prognostic frameworks could enhance individualized treatment planning for those with multiple myeloma. Overall, the evidence indicates that MDM2 functions as both a marker of aggressive tumor biology and a promising indicator for early-stage risk stratification, supporting more vigilant follow-up and personalized therapeutic intervention to reduce relapse likelihood.
Citation	Ebrahim NAA, Elfandy H, Arafat A, Darwish AD, Eltohamy MI. Evaluating murine double minute 2 status as a stratification tool for risk-adapted management in plasma cell neoplasms. World J Clin Oncol 2025; In press

Received	2025-07-07 07:51
Peer-Review Started	2025-07-07 07:51
First Decision by Editorial Office Director	2025-07-22 09:20
Return for Revision	2025-07-22 09:20
Revised	2025-07-29 00:02
Publication Fee Transferred
Second Decision by Editor	2025-12-11 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-11 12:19
Articles in Press	2025-12-11 12:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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