Publication Name	World Journal of Clinical Cases
Manuscript ID	111438
Country	Japan

Category	Infectious Diseases
Manuscript Type	Case Report
Article Title	Recurrence of acyclovir-resistant herpes encephalitis in an immunocompromised patient: A case report
Manuscript Source	Invited Manuscript
All Author List	Daisuke Usuda, Daiki Furukawa, Rikako Imaizumi, Rikuo Ono, Yuki Kaneoka, Eri Nakajima, Masashi Kato, Yuto Sugawara, Runa Shimizu, Tomotari Inami, Kenji Kawai, Shun Matsubara, Risa Tanaka, Makoto Suzuki, Shintaro Shimozawa, Yuta Hotchi, Ippei Osugi, Risa Katou, Sakurako Ito, Kentaro Mishima, Akihiko Kondo, Keiko Mizuno, Hiroki Takami, Takayuki Komatsu, Tomohisa Nomura and Manabu Sugita
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science KAKENHI Grant JP24K15491
Corresponding Author	Daisuke Usuda, Associate Professor, MD, PhD, Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima 177-8521, Tokyo, Japan. d.usuda.qa@juntendo.ac.jp
Key Words	Acyclovir-resistant herpes encephalitis; Recurrence; Immunocompromised status; Neurosurgical interventions; Treatment; Case report
Core Tip	Acyclovir-resistant herpes simplex virus strains have emerged and gradually increased. We report the first case of acyclovir-resistant herpes encephalitis (ARHE) recurring in an immunocompromised adult patient without neurosurgical interventions. Clinicians should recognize this condition because treatment for ARHE is limited, and it often develops into severe herpes disease that is refractory to antiviral drug therapy. In addition, ARHE recurred in the patient following remission; therefore, it is necessary to discuss the length of the treatment period. There is no established standard treatment for recurrence cases; therefore, accumulation of evidence is needed.
Citation	Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Recurrence of acyclovir-resistant herpes encephalitis in an immunocompromised patient: A case report. World J Clin Cases 2025; In press

Received	2025-07-01 01:20
Peer-Review Started	2025-07-01 01:20
To Make the First Decision
Return for Revision	2025-08-27 02:59
Revised	2025-09-04 10:31
Second Decision	2025-11-20 23:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-21 02:41
Articles in Press	2025-11-21 02:41
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ISSN	2307-8960 (online)
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