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Publication Name World Journal of Diabetes
Manuscript ID 111453
Country China
Category Endocrinology & Metabolism
Manuscript Type Basic Study
Article Title Integrated hepatic transcriptome and metabolome reveal the mechanisms of Jiangtang Tiaozhi formula on improving glycolipid metabolic disorder
Manuscript Source Unsolicited Manuscript
All Author List Jia-Xing Tian, Yan-Jiao Zhang, Yu-Xin Zhang, Jia-Hua Wei, Xin-Yi Fang, Run-Yu Miao, Kai-Le Ma, Hui-Fang Guan, Xin-Miao Wang and Hao-Ran Wu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China No. 82474323
CACMS Outstanding Young Scientific and Technological Talents Program No. ZZ13-YQ-026
High Level Chinese Medical Hospital Promotion Project No. HLCMHPP20230CZ40907
Open Project of National Facility for Translational Medicine No. TMSK-2021-407
Qiushi Project of the China Association of Chinese Medicine No. 2024-QNQS-12
Corresponding Author
Key Words Glycolipid metabolic disorder; Hepatic transcriptome; Hepatic metabolome; Jiangtang Tiaozhi formula; Multi-omics
Core Tip This study explores the effects of Jiangtang Tiaozhi formula (JTTZF) on glycolipid metabolic disorder in high-fat diet-induced mice. By integrating hepatic transcriptome and metabolome analyses, we find that JTTZF regulates key genes and metabolites linked to glucose and lipid metabolism. Our results highlight the potential of JTTZF as a therapeutic agent for glycolipid metabolic disorder and provide valuable insights into its underlying mechanisms.
Citation Tian JX, Zhang YJ, Zhang YX, Wei JH, Fang XY, Miao RY, Ma KL, Guan HF, Wang XM, Wu HR. Integrated hepatic transcriptome and metabolome reveal the mechanisms of Jiangtang Tiaozhi formula on improving glycolipid metabolic disorder. World J Diabetes 2025; In press
Received
2025-06-30 01:14
Peer-Review Started
2025-07-01 00:06
First Decision by Editorial Office Director
2025-08-01 09:05
Return for Revision
2025-08-01 09:05
Revised
2025-09-01 10:56
Publication Fee Transferred
2025-09-15 13:07
Second Decision by Editor
2025-11-24 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-12-08 08:34
Articles in Press
2025-12-08 08:34
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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