Publication Name	World Journal of Transplantation
Manuscript ID	111524
Country	Pakistan

Category	Transplantation
Manuscript Type	Review
Article Title	Update on diagnostic and therapeutic strategies for antibody-mediated rejection in kidney transplantation
Manuscript Source	Invited Manuscript
All Author List	Tabassum Elahi, Saima Ahmed and Muhammed Mubarak
Funding Agency and Grant Number
Corresponding Author	Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com
Key Words	Antibodies; Kidney; Transplantation; Rejection; Diagnosis
Core Tip	Antibody-mediated rejection remains a leading cause of kidney graft dysfunction and failure. While donor-specific antibodies are a key risk factor, not all are pathogenic. Current diagnostic markers lack sensitivity and often miss subclinical changes, with definitive diagnosis still relying on invasive biopsy. The clinical adoption of noninvasive biomarkers continues to face significant hurdles. Despite advances in understanding antibody-mediated rejection biology, no standardized or approved treatment currently exists. Present guidelines are largely based on earlier consensus, although emerging therapies such as CD38 antibodies and complement inhibitors show promise, particularly in early or severe cases.
Citation	Elahi T, Ahmed S, Mubarak M. Update on diagnostic and therapeutic strategies for antibody-mediated rejection in kidney transplantation. World J Transplant 2025; In press

Received	2025-07-02 01:48
Peer-Review Started	2025-07-02 01:48
First Decision by Editorial Office Director	2025-08-14 08:38
Return for Revision	2025-08-14 08:38
Revised	2025-08-23 16:42
Publication Fee Transferred
Second Decision by Editor	2025-12-01 02:57
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-01 10:53
Articles in Press	2025-12-01 10:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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