Publication Name	World Journal of Clinical Oncology
Manuscript ID	111544
Country	China

Category	Oncology
Manuscript Type	Case Control Study
Article Title	Group-specific component and 25-hydroxylase gene polymorphisms in nasopharyngeal carcinoma: Associations with susceptibility and radiotherapy response
Manuscript Source	Unsolicited Manuscript
All Author List	Liu Liu, Dian-Yu Shi, Jie Tan, Shan Xu and Chao-Ran Liu
Funding Agency and Grant Number
Corresponding Author	Chao-Ran Liu, PhD, Researcher, Department of Otolaryngology-Head and Neck Surgery, Longhua District People's Hospital, No. 38 Jianshe East Road, Longhua District, Shenzhen 518110, Guangdong Province, China. chaoranliuszlhrmyy@163.com
Key Words	Group-specific component protein; 25-hydroxylase; Single nucleotide polymorphism; Nasopharyngeal carcinoma; Susceptibility; Radiotherapy response
Core Tip	This study reveals that polymorphisms in the vitamin D-binding protein gene [group-specific component (GC), rs4588] and 25-hydroxylase gene (CYP2R1) (rs12794714) are associated with nasopharyngeal carcinoma (NPC) susceptibility and radiotherapy response, particularly in individuals with sufficient serum 25-hydroxyvitamin D levels. The GC rs4588 TT genotype increases NPC risk, while the CYP2R1 rs12794714 AA genotype predicts radiotherapy resistance. These findings highlight the interplay between genetic predisposition and vitamin D status, offering new strategies for precision prevention and personalized treatment in NPC.
Citation	Liu L, Shi DY, Tan J, Xu S, Liu CR. Group-specific component and 25-hydroxylase gene polymorphisms in nasopharyngeal carcinoma: Associations with susceptibility and radiotherapy response. World J Clin Oncol 2025; In press

Received	2025-07-09 08:48
Peer-Review Started	2025-07-09 08:48
To Make the First Decision
Return for Revision	2025-08-04 07:43
Revised	2025-08-19 09:54
Second Decision	2025-11-13 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 09:10
Articles in Press	2025-11-13 09:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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