Publication Name	World Journal of Hepatology
Manuscript ID	111569
Country	Brazil

Category	Multidisciplinary Sciences
Manuscript Type	Retrospective Study
Article Title	Inflammatory parameters and liver fibrosis in patients with steatosis: A cross-sectional analysis
Manuscript Source	Invited Manuscript
All Author List	Melina Borba Duarte, Juliana Czermainski, Luis F Ferreira, Cristiane V Tovo and Randhall B Carteri
Funding Agency and Grant Number
Corresponding Author	Cristiane V Tovo, Department of Internal Medicine, Federal University of Health Sciences of Porto Alegre, R. Sarmento Leite, 245 - Centro Histórico, Porto Alegre - RS, 90050-170, Porto Alegre 90050-170, Rio Grande do Sul, Brazil. cristianev@ufcspa.edu.br
Key Words	Hepatology; Systemic inflammation; Neutrophil-to-lymphocyte ratio; C-reactive protein; Liver fibrosis; Inflammatory markers; Systemic inflammation
Core Tip	This study evaluated low-cost inflammatory indices derived from whole blood cell counts-such as neutrophile to lymphocyte ratio, aggregate index of systemic inflammation, and systemic inflammation response index, as potential non-invasive tools to predict liver fibrosis in adults with metabolic dysfunction-associated steatotic liver disease using National Health and Nutrition Examination Survey data. Although these indices showed statistically significant associations with liver damage, their overall predictive accuracy was limited, with no positive predictive value and low area under the curve. C-reactive protein consistently outperformed the cell-based indices. These findings suggest that while inflammatory ratios are easy to calculate, they are insufficient as standalone markers for fibrosis prediction, highlighting the need to explore more accurate and cost-effective direct biomarkers.
Citation	Duarte MB, Czermainski J, Ferreira LF, Tovo CV, Carteri RB. Inflammatory parameters and liver fibrosis in patients with steatosis: A cross-sectional analysis. World J Hepatol 2026; In press

Received	2025-07-03 12:34
Peer-Review Started	2025-07-03 12:34
First Decision by Editorial Office Director	2025-07-16 08:41
Return for Revision	2025-07-16 08:41
Revised	2025-08-20 14:53
Publication Fee Transferred
Second Decision by Editor	2026-01-16 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-16 07:14
Articles in Press	2026-01-16 07:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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