Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	111614
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Predictive factors and outcomes of endoscopic necrosectomy in patients with acute pancreatitis and walled-off necrosis
Manuscript Source	Invited Manuscript
All Author List	Shabir A Lone, Ujjwal Sonika, Ravi Teja Reddy, Venkatesh Vaithiyam, Payila SR Aneesh, Sri Harsha Palli, Ashok Dalal, Ajay Kumar, Siddharth Srivastava and Sanjeev Sachdeva
Funding Agency and Grant Number
Corresponding Author	Venkatesh Vaithiyam, Assistant Professor, Department of Gastroenterology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, 1, Jawaharlal Nahru Marg, 64 Khamba, Raj Ghat, New Delhi 110002, Delhi, India. venkateshvaithiyam172@gmail.com
Key Words	Acute pancreatitis; Walled-off necrosis; Necrosectomy; Endoscopy; Lumen-apposing metal stent
Core Tip	Walled-off necrosis (WON) is a well-known complication of acute pancreatitis. Although many patients respond to endoscopic drainage alone, some require direct endoscopic necrosectomy for optimal outcomes. This retrospective study identified the clinical, biochemical, and radiological predictors of necrosectomy in patients undergoing placement of lumen-apposing metal stents. Of the examined factors, fever, anemia, hypoalbuminemia, systemic inflammatory response syndrome, pancreatic necrosis > 30%, WON size, and WON location were predictors of necrosectomy. Early identification of these predictors can guide clinicians in planning timely interventions, thereby improving outcomes and reducing morbidity associated with delayed or unnecessary necrosectomy.
Citation	Lone SA, Sonika U, Reddy RT, Vaithiyam V, Aneesh PSR, Palli SH, Dalal A, Kumar A, Srivastava S, Sachdeva S. Predictive factors and outcomes of endoscopic necrosectomy in patients with acute pancreatitis and walled-off necrosis. World J Gastrointest Endosc 2025; In press

Received	2025-07-07 08:20
Peer-Review Started	2025-07-07 08:20
To Make the First Decision
Return for Revision	2025-07-18 07:44
Revised	2025-07-30 12:54
Second Decision	2025-11-13 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 10:37
Articles in Press	2025-11-13 10:37
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ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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