Publication Name	World Journal of Diabetes
Manuscript ID	111698
Country	Italy

Category	Medicine, General & Internal
Manuscript Type	Randomized Clinical Trial
Article Title	Impact of achieving glycated hemoglobin targets on cardiovascular events/mortality: Post-hoc analysis of the nephropathy in diabetes type 2 trial
Manuscript Source	Invited Manuscript
All Author List	Alfredo Caturano, Vittorio Simeon, Raffaele Galiero, Vincenzo Russo, Luca De Nicola, Paolo Chiodini, Luca Rinaldi, Erica Vetrano, Teresa Salvatore, Caterina Conte, Carlo Acierno, Celestino Sardu, Raffaele Marfella, Roberto Minutolo and Ferdinando C Sasso
Funding Agency and Grant Number	Funding Agency Grant Number Ministero dell’ Università e della Ricerca (Italian Ministry of University and Research) No. 2007PSYLRX
Corresponding Author	Caterina Conte, Professor, Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma University, Via di val Cannuta, 247, Rome 00166, Italy. caterina.conte@uniroma5.it
Key Words	Type 2 diabetes mellitus; Glycated hemoglobin; Multifactorial intervention; Cardiovascular diseases; Risk factors; Diabetic complications
Core Tip	In high-risk patients with type 2 diabetes, achieving a glycated hemoglobin ≤ 7% was associated with fewer cardiovascular events only under standard care conditions, suggesting that the cardiovascular benefit of glycemic control may depend on treatment intensity. In contrast, younger age, female sex, and blood pressure control were more consistent predictors of improved outcomes. Low-density lipoprotein cholesterol control showed a borderline association with reduced mortality in the standard of care group only.
Citation	Caturano A, Simeon V, Galiero R, Russo V, De Nicola L, Chiodini P, Rinaldi L, Vetrano E, Salvatore T, Conte C, Acierno C, Sardu C, Marfella R, Minutolo R, Sasso FC. Impact of achieving glycated hemoglobin targets on cardiovascular events/mortality: Post-hoc analysis of the nephropathy in diabetes type 2 trial. World J Diabetes 2025; In press

Received	2025-07-09 04:01
Peer-Review Started	2025-07-10 00:08
To Make the First Decision
Return for Revision	2025-07-29 09:18
Revised	2025-08-11 18:37
Second Decision	2025-09-18 00:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-13 09:30
Articles in Press	2025-10-13 09:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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