Publication Name	World Journal of Nephrology
Manuscript ID	111723
Country	Thailand

Category	Transplantation
Manuscript Type	Case Report
Article Title	Tacrolimus toxicity in kidney transplant recipient after wedge liver resection: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Nuanjanthip Naiyarakseree, Thunyatorn Wuttiputhanun, Natavudh Townamchai, Methee Sutherasan, Yingyos Avihingsanon and Suwasin Udomkarnjananun
Funding Agency and Grant Number
Corresponding Author	Suwasin Udomkarnjananun, Assistant Professor, Lecturer, MD, PhD, Researcher, Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873, Rama 4 road, Pathumwan, Bangkok 10330, Krung Thep Maha Nakhon, Thailand. suwasin.u@gmail.com
Key Words	Tacrolimus; Kidney transplant; Liver resection; Hepatectomy; Nephrotoxicity; Neurotoxicity; Case report
Core Tip	We report the first case of tacrolimus toxicity in a kidney-transplant recipient after wedge liver resection for hepatocellular carcinoma. Reduced liver mass and transient ischemic injury impaired metabolism of tacrolimus, a calcineurin inhibitor, causing rapid rises in trough concentration, acute kidney injury, and neurotoxicity that reversed with dose interruption. The case underscores the need for proactive therapeutic drug monitoring, early dose adjustment, and structured evaluation of postoperative acute kidney injury in transplant recipients undergoing hepatic surgery.
Citation	Naiyarakseree N, Wuttiputhanun T, Townamchai N, Sutherasan M, Avihingsanon Y, Udomkarnjananun S. Tacrolimus toxicity in kidney transplant recipient after wedge liver resection: A case report and review of literature. World J Nephrol 2025; In press

Received	2025-07-08 05:44
Peer-Review Started	2025-07-08 05:45
To Make the First Decision
Return for Revision	2025-08-14 08:30
Revised	2025-08-23 03:22
Second Decision	2025-10-20 02:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-21 02:32
Articles in Press	2025-10-21 02:32
Publication Fee Transferred	2025-08-25 02:16
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Typeset the Manuscript

ISSN	2220-6124 (online)
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