Publication Name	World Journal of Diabetes
Manuscript ID	111771
Country	China

Category	Pediatrics
Manuscript Type	Basic Study
Article Title	Oral Akkermansia muciniphila may ameliorates immune dysregulation in a murine model of streptozotocin-induced type 1 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Bao-Jiang Huang, Song Guo, Xiao-Ya Lin, Yan-Hong Li, Hua-Mei Ma, Jun Zhang and Qiu-Li Chen
Funding Agency and Grant Number
Corresponding Author	Qiu-Li Chen, Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Second Road, Guangzhou 510000, Guangdong Province, China. chenqiul@mail.sysu.edu.cn
Key Words	Type 1 diabetes; Streptozotocin; Akkermansia muciniphila; Autoimmune; Intestinal barrier
Core Tip	This study pioneers Akkermansia muciniphila (A. muciniphila) intervention evaluation in streptozotocin-induced type 1 diabetes mellitus (T1DM) mice. Despite no reversal of hyperglycemia or islet damage after short-term (3-day) oral administration, A. muciniphila ameliorated immune imbalance by enhancing intestinal barrier function (increased zonula occludens-1, decreased zonulin), suppressing pro-inflammatory cytokines (tumor necrosis factor-alpha, interferon-gamma), increasing anti-inflammatory interleukin-4 and regulatory T cells, modulating signaling pathways (reduced signal transducer and activator of transcription 1, suppressed nuclear factor kappa-B p65), and decreasing intestinal Actinobacteria abundance. These findings highlight A. muciniphila’s potential for immune regulation in established T1DM by gut barrier repair and microbial shifts.
Citation	Huang BJ, Guo S, Lin XY, Li YH, Ma HM, Zhang J, Chen QL. Oral Akkermansia muciniphila may ameliorates immune dysregulation in a murine model of streptozotocin-induced type 1 diabetes. World J Diabetes 2025; In press

Received	2025-07-09 04:33
Peer-Review Started	2025-07-10 00:08
To Make the First Decision
Return for Revision	2025-07-25 06:36
Revised	2025-08-06 12:12
Second Decision	2025-11-06 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 06:15
Articles in Press	2025-11-13 06:15
Publication Fee Transferred	2025-08-07 15:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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