Publication Name	World Journal of Psychiatry
Manuscript ID	111801
Country	China

Category	Psychology, Clinical
Manuscript Type	Clinical Trials Study
Article Title	Efficacy and mechanism of Shugan Jieyu combined with sertraline in alcohol-dependent patients with depression: A randomized clinical study
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Zhang, Hao-Yu Xing and Juan Yan
Funding Agency and Grant Number
Corresponding Author	Juan Yan, Manager, MD, Professor, Graduate School, Zhejiang Chinese Medical University, No. 305 Tianmushan Road, Xihu District, Hangzhou 311402, Zhejiang Province, China. 294162939@qq.com
Key Words	Shugan Jieyu capsules; Sertraline; Alcohol dependence; Depression; Efficacy; Mechanism
Core Tip	This study investigates the efficacy and safety of combining Shugan Jieyu capsules (SJC) with sertraline in treating alcohol dependence and comorbid depression. The results show that the combination significantly reduces depression symptoms, with improved outcomes seen as early as 2 weeks. The study group demonstrated a higher total efficacy rate (90%) compared to the control group (73.3%), with no significant difference in adverse reactions between the two groups. These findings suggest that SJC, when used alongside sertraline, offer a promising, safe, and effective treatment option for patients with alcohol-induced depression.
Citation	Zhang Y, Xing HY, Yan J. Efficacy and mechanism of Shugan Jieyu combined with sertraline in alcohol-dependent patients with depression: A randomized clinical study. World J Psychiatry 2025; In press

Received	2025-07-11 05:38
Peer-Review Started	2025-07-11 05:38
To Make the First Decision
Return for Revision	2025-08-04 06:56
Revised	2025-08-15 03:53
Second Decision	2025-10-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-11 07:12
Articles in Press	2025-10-11 07:12
Publication Fee Transferred	2025-08-20 08:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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