Publication Name	World Journal of Diabetes
Manuscript ID	111808
Country	China

Category	Ophthalmology
Manuscript Type	Observational Study
Article Title	Association of serum and vitreous homocysteine and uric acid concentrations with post-vitrectomy prognosis in patients with proliferative diabetic retinopathy
Manuscript Source	Unsolicited Manuscript
All Author List	Qi-Bo Ran, Chun-Yan Lei, Sheng Gao, Xiang-Gang Yang, Fei-Peng Jiang and Mei-Xia Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Sichuan Provincial Science and Technology Support Project 2024YFFK0303
Corresponding Author	Mei-Xia Zhang, Chief Physician, MD, Professor, Department of Ophthalmology, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. zhangmeixia@scu.edu.cn
Key Words	Proliferative diabetic retinopathy; Homocysteine; Uric acid; Pars plana vitrectomy; Prognosis; Optical coherence tomography; Optical coherence tomography angiography; Diabetic retinopathy
Core Tip	This study demonstrates that vitreous homocysteine and uric acid are significantly elevated in patients with proliferative diabetic retinopathy, reflecting localized ocular pathology. Unlike their serum counterparts, elevated vitreous homocysteine specifically correlates with worse early visual acuity, progressive retinal nerve fiber layer thinning, and delayed microvascular impairment after pars plana vitrectomy, positioning it as a superior, compartment-specific predictor of multidimensional postoperative outcomes.
Citation	Ran QB, Lei CY, Gao S, Yang XG, Jiang FP, Zhang MX. Association of serum and vitreous homocysteine and uric acid concentrations with post-vitrectomy prognosis in patients with proliferative diabetic retinopathy. World J Diabetes 2025; In press

Received	2025-07-10 08:15
Peer-Review Started	2025-07-11 00:28
First Decision by Editorial Office Director	2025-08-22 08:58
Return for Revision	2025-08-22 08:58
Revised	2025-09-20 16:50
Publication Fee Transferred
Second Decision by Editor	2025-12-02 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-02 07:31
Articles in Press	2025-12-02 07:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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