Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	111829
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Intra-abdominal pressure and procalcitonin for prognosis in severe acute pancreatitis patients: An etiology-based analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Feng Zhao, Guo-Xing Jin, Yao Wang and Xue-Ming Huang
Funding Agency and Grant Number	Funding Agency Grant Number Huzhou Science and Technology Bureau Public Welfare Applied Research Project-General Medical and Health Program No. 2021GY21
Corresponding Author	Guo-Xing Jin, Chief Physician, Department of General Surgery, Huzhou Wuxing District People 's Hospital, Wuxing District Maternal and Child Health Hospital of Huzhou City, No. 1599 Dagang Road, Wuxing District, Huzhou 313000, Zhejiang Province, China. tony1128lu@gmail.com
Key Words	Severe acute pancreatitis; Intra-abdominal pressure; Procalcitonin; Etiological heterogeneity; Hypertriglyceridemic pancreatitis
Core Tip	By integrating intra-abdominal pressure (IAP) and procalcitonin (PCT) using a machine learning algorithm, this study establishes a superior prognostic model for severe acute pancreatitis (AP). The core innovation, however, lies in revealing profound etiological heterogeneity. We demonstrate that the correlation between IAP and PCT, and the benefits of guided management, are most significant in patients with hypertriglyceridemic AP (HTG-AP). These findings advocate for a shift from a uniform approach to an etiology-stratified precision medicine strategy, particularly for the high-risk HTG-AP subgroup.
Citation	Zhao JF, Jin GX, Wang Y, Huang XM. Intra-abdominal pressure and procalcitonin for prognosis in severe acute pancreatitis patients: An etiology-based analysis. World J Gastrointest Surg 2025; In press

Received	2025-07-10 08:43
Peer-Review Started	2025-07-10 08:43
To Make the First Decision
Return for Revision	2025-09-05 00:48
Revised	2025-09-17 19:12
Second Decision	2025-10-20 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 08:52
Articles in Press	2025-10-20 08:52
Publication Fee Transferred	2025-09-22 11:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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