Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	111833
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Multimodality ultrasound in Crohn’s disease strictures
Manuscript Source	Invited Manuscript
All Author List	Partha Pal, Priyaranjan Kata, Mohammad Abdul Mateen, Vamsi Krishna Ankam, Deepak Lalan Jha, Rajesh Gupta, Manu Tandan and Nageshwar Reddy Duvvur
Funding Agency and Grant Number
Corresponding Author	Partha Pal, FASGE, MD, MRCP, Department of Medical Gastroenterology, Asian Institute of Gastroenterology, 6-3-661 Red Rose Cafe Lane, Sangeet Nagar, Somajiguda, Hyderabad 500082, Telangāna, India. partha0123456789@gmail.com
Key Words	Crohn’s disease; Intestinal ultrasound; Small intestine contrast ultrasonography; Contrast-enhanced ultrasound; Elastography
Core Tip	Multimodal intestinal ultrasound - including contrast-enhanced ultrasound, small intestine contrast ultrasonography, and ultrasound-based elastography - offers a noninvasive, radiation-free, and accurate approach to characterize Crohn’s disease strictures. Small intestine contrast ultrasonography reliably detects strictures and disease extent with performance comparable to cross-sectional imaging. Contrast-enhanced ultrasound perfusion parameters such as peak enhancement and AUC help differentiate inflammation from fibrosis, especially when combined with elastography. Shear wave elastography provides quantitative stiffness assessment, with velocities > 2.5  m/second indicating fibrosis. These tools support precise stricture phenotyping and may guide tailored therapy and surgical decision-making.
Citation	Pal P, Kata P, Mateen MA, Ankam VK, Jha DL, Gupta R, Tandan M, Duvvur NR. Multimodality ultrasound in Crohn’s disease strictures. World J Gastrointest Pharmacol Ther 2026; In press

Received	2025-07-11 05:28
Peer-Review Started	2025-07-11 05:28
First Decision by Editorial Office Director	2025-08-19 09:54
Return for Revision	2025-08-19 10:27
Revised	2025-08-21 04:20
Publication Fee Transferred
Second Decision by Editor	2026-01-06 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-06 11:11
Articles in Press	2026-01-06 11:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
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