Publication Name	World Journal of Clinical Cases
Manuscript ID	111835
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Primary ileal squamous cell carcinoma: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Qian-Qian Li, Jie Wei, Lu-Yao Fang, Jia-Lv Zhou and Huan-Fen Zhao
Funding Agency and Grant Number
Corresponding Author	Huan-Fen Zhao, Chief Physician, Professor, Department of Pathology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050051, Hebei Province, China. hbghbinglike@126.com
Key Words	Small intestinal neoplasms; Ileal squamous cell carcinoma; Immunophenotype; Clinical characteristics; Pathogenesis; Clinicopathology; Case report
Core Tip	Primary ileal squamous cell carcinoma represents a paradox, as it arises in the ileal mucosa that lacks native squamous epithelium. With an incidence of less than 0.001% among intestinal malignancies and only 12 confirmed cases worldwide (as of 2025), this rare entity remains poorly characterized in the literature. Here, we report a newly diagnosed case of primary ileal squamous cell carcinoma and synthesize its clinicopathologic features, clinical presentation, therapeutic management, and the patient’s outcome and prognosis, with particular emphasis on diagnostic dilemmas and treatment efficacy.
Citation	Li QQ, Wei J, Fang LY, Zhou JL, Zhao HF. Primary ileal squamous cell carcinoma: A case report and review of literature. World J Clin Cases 2025; In press

Received	2025-07-11 05:31
Peer-Review Started	2025-07-11 05:31
First Decision by Editorial Office Director	2025-09-09 09:54
Return for Revision	2025-09-09 09:54
Revised	2025-09-22 11:30
Publication Fee Transferred	2025-09-29 08:17
Second Decision by Editor	2025-12-15 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-15 07:12
Articles in Press	2025-12-15 07:12
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Typeset the Manuscript

ISSN	2307-8960 (online)
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