Publication Name	World Journal of Hepatology
Manuscript ID	111871
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Impact of clinically significant portal hypertension on posthepatectomy liver failure: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Ming-Hao Ruan, Fei-Yang Ye, Jin-Ni Ma, Jin Qian, Ming-Hao Zou, Wen-Xuan Zhou, Jie Sheng, Xin-Gang Guo, Dong Wei, Cheng-Jing Zhang, Hui Liu and Fu-Chen Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82302906 National Natural Science Foundation of China 82270634 2024 Research Plan Project of the Jiading District Natural Science Foundation 2024-KY-JB-30
Corresponding Author	Fu-Chen Liu, The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, No. 225 Changhai Road, Yangpu District, Shanghai 200438, China. liufuchenlfc@163.com
Key Words	Clinically significant portal hypertension; Posthepatectomy liver failure; Partial hepatectomy; Systematic review; Meta-analysis
Core Tip	The health challenges of partial hepatectomy in patients with clinically significant portal hypertension (CSPH) have been a subject of study for decades. There was no meta-analysis has systematically examined the relationship between CSPH and posthepatectomy liver failure (PHLF), despite its potential role as a critical factor in surgical decision-making. This systematic review and meta-analysis assessed PHLF in patients with and without CSPH and showed the presence of CSPH should be considered as a significant risk factor and should be taken into account seriously prior to surgery and needs strict perioperative management. Meanwhile, different methods of diagnosing CSPH could influence PHLF.
Citation	Ruan MH, Ye FY, Ma JN, Qian J, Zou MH, Zhou WX, Sheng J, Guo XG, Wei D, Zhang CJ, Liu H, Liu FC. Impact of clinically significant portal hypertension on posthepatectomy liver failure: A systematic review and meta-analysis. World J Hepatol 2025; In press

Received	2025-07-14 03:17
Peer-Review Started	2025-07-14 03:18
To Make the First Decision
Return for Revision	2025-08-08 08:42
Revised	2025-08-21 22:53
Second Decision	2025-11-25 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-26 08:12
Articles in Press	2025-11-26 08:12
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ISSN	1948-5182 (online)
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