Publication Name	World Journal of Hepatology
Manuscript ID	111902
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Harnessing artificial intelligence in gastroenterology and hepatology: Current applications and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Panagiotis Boutos, Konstantina-Eleni Karakasi, Georgios Katsanos, Nikolaos Antoniadis, Athanasios Kofinas and Georgios Tsoulfas
Funding Agency and Grant Number
Corresponding Author	Panagiotis Boutos, Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Aristotle University School of Medicine, Konstantinoupoleos 49, Thessaloniki 54642, Kentrikí Makedonía, Greece. pgmpoutos@gmail.com
Key Words	Trustworthiness; Interpretability; Endoscopy; Medical imaging; Clinical decision support; Hepatology; Gastroenterology; Deep learning; Machine learning; Artificial intelligence
Core Tip	This article presents a structured overview of artificial intelligence (AI) in gastroenterology and hepatology, integrating fundamental concepts with real-world clinical applications. By aligning AI tools with each stage of the patient journey, we highlight how AI can enhance prevention, diagnosis, treatment, and follow-up. We also discuss challenges related to trustworthiness, including interpretability, generalisability, and ethics. Through practical examples and original visual frameworks, this article aims to guide clinicians and researchers in understanding, evaluating, and responsibly implementing AI technologies in digestive and liver healthcare.
Citation	Boutos P, Karakasi KE, Katsanos G, Antoniadis N, Kofinas A, Tsoulfas G. Harnessing artificial intelligence in gastroenterology and hepatology: Current applications and future perspectives. World J Hepatol 2025; In press

Received	2025-07-14 05:20
Peer-Review Started	2025-07-14 05:20
First Decision by Editorial Office Director	2025-08-05 09:24
Return for Revision	2025-08-07 21:35
Revised	2025-08-29 01:39
Publication Fee Transferred
Second Decision by Editor	2025-12-01 03:10
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-02 04:19
Articles in Press	2025-12-02 04:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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