Publication Name	World Journal of Orthopedics
Manuscript ID	111911
Country	India

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Molecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis
Manuscript Source	Invited Manuscript
All Author List	Naveen Jeyaraman, Madhan Jeyaraman, Swaminathan Ramasubramanian, Shrideavi Murugan, Arulkumar Nallakumarasamy and Sathish Muthu
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, MD, PhD, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Poonamalle High Road, Velappanchavadi, Chennai 600077, Tamil Nādu, India. madhanjeyaraman@gmail.com
Key Words	Molecular hydrogen; Musculoskeletal disorders; Oxidative stress; Anti-inflammation; Clinical evidence
Core Tip	Molecular hydrogen therapy exhibits potent antioxidant, anti-inflammatory, and cytoprotective effects across diverse musculoskeletal conditions. This review synthesizes evidence from 45 studies - spanning osteoarthritis, rheumatoid arthritis, muscle damage, chronic pain, and atrophy - highlighting promising symptomatic relief and mechanistic plausibility. However, variability in delivery methods, sample sizes, and endpoints demands standardized trials with biomarker-driven designs to validate molecular hydrogen’s efficacy and guide clinical integration.
Citation	Jeyaraman N, Jeyaraman M, Ramasubramanian S, Murugan S, Nallakumarasamy A, Muthu S. Molecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis. World J Orthop 2025; In press

Received	2025-07-14 04:19
Peer-Review Started	2025-07-14 04:20
To Make the First Decision
Return for Revision	2025-08-20 07:26
Revised	2025-09-15 17:47
Second Decision	2025-11-13 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 08:15
Articles in Press	2025-11-13 08:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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