Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	111928
Country	Denmark

Category	Surgery
Manuscript Type	Basic Study
Article Title	Septic shock reduces intestinal microcirculation and anastomotic perfusion: A porcine laser speckle contrast imaging study
Manuscript Source	Unsolicited Manuscript
All Author List	Rupan Paramasivam, Claudia Jaensch, Nickolai M Kristensen, Susie Sarah Paramasivam, Helen Woldeselassie, Louise Kruse Jensen, Anders Husted Madsen and Mai-Britt Worm Ørntoft
Funding Agency and Grant Number
Corresponding Author	Rupan Paramasivam, MD, Researcher, Department of Surgery, Godstrup Hospital, Hospitalsparken 15, Herning 7400, Midtjylland, Denmark. ruppar@rm.dk
Key Words	Sepsis; Intestinal anastomoses; Microcirculation; Anastomotic perfusion; Porcine model; Laser speckle contrast imaging
Core Tip	Septic shock profoundly affects intestinal blood flow, yet its impact on surgical anastomoses remains unclear. In this study, we used laser speckle contrast imaging in a porcine model to assess microcirculation in the small intestine and colon during induced septic shock. We demonstrate a significant reduction in microcirculation, especially at anastomotic sites, with hand-sewn anastomoses maintaining higher perfusion than stapled ones. These findings highlight the potential risk of impaired anastomotic healing during sepsis and emphasize the importance of optimizing surgical strategies in septic patients.
Citation	Paramasivam R, Jaensch C, Kristensen NM, Paramasivam SS, Woldeselassie H, Jensen LK, Madsen AH, Ørntoft MBW. Septic shock reduces intestinal microcirculation and anastomotic perfusion: A porcine laser speckle contrast imaging study. World J Gastrointest Surg 2025; In press

Received	2025-07-14 09:08
Peer-Review Started	2025-07-14 09:08
To Make the First Decision
Return for Revision	2025-07-28 07:12
Revised	2025-08-06 21:58
Second Decision	2025-11-27 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-27 06:58
Articles in Press	2025-11-27 06:58
Publication Fee Transferred	2025-08-15 20:40
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Typeset the Manuscript

ISSN	1948-9366 (online)
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