Publication Name	World Journal of Gastroenterology
Manuscript ID	111934
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Inflammatory bowel disease in paediatrics: Navigating the old challenges and emerging frontiers
Manuscript Source	Invited Manuscript
All Author List	Mohammed Al-Beltagi, Nermin K Saeed, Prabu Kumar Chokkalingam Mani, Adel S Bediwy and Reem Elbeltagi
Funding Agency and Grant Number
Corresponding Author	Mohammed Al-Beltagi, Chairman, Consultant, Head, MD, PhD, Professor, Department of Pediatrics, Faculty of Medicine, Tanta University, 1 Hassan Radwan Street, Tanta 31511, Algharbia, Egypt. mbelrem@hotmail.com
Key Words	Pediatric inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease-unclassified; Very early-onset inflammatory bowel disease; Precision medicine; Nutritional therapy; Biologic therapy; Psychosocial impact; Multidisciplinary care
Core Tip	Pediatric inflammatory bowel disease (IBD) is increasing globally, with rising incidence in previously low-prevalence regions such as the Arabian Gulf. This review highlights the unique challenges in pediatric IBD diagnosis, including atypical presentations and very early-onset IBD, and emphasizes the need for age-specific treatment approaches. It also explores emerging frontiers such as personalized medicine, biologic therapies, and multidisciplinary care. By integrating recent data on epidemiology, pathogenesis, and psychosocial impact, this article presents a comprehensive framework for optimizing outcomes in children with IBD, guiding future research and policy priorities in this evolving field.
Citation	Al-Beltagi M, Saeed NK, Mani PKC, Bediwy AS, Elbeltagi R. Inflammatory bowel disease in paediatrics: Navigating the old challenges and emerging frontiers. World J Gastroenterol 2025; In press

Received	2025-07-14 03:02
Peer-Review Started	2025-07-14 03:02
To Make the First Decision
Return for Revision	2025-07-22 09:57
Revised	2025-07-27 16:12
Second Decision	2025-08-19 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-19 03:16
Articles in Press	2025-08-19 03:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com