Publication Name	World Journal of Gastroenterology
Manuscript ID	111951
Country	Thailand

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Prognostic role of histone deacetylase 10 in colorectal cancer: Strengths and ‎gaps
Manuscript Source	Unsolicited Manuscript
All Author List	Ali Afzal, Chatchai Muanprasat and Muhammad Babar Khawar
Funding Agency and Grant Number
Corresponding Author	Chatchai Muanprasat, Professor, Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road/Phutthamonthon 4 Road, Bangpla 10540, Bangplee, Thailand. chatchai.mua@mahidol.ac.th
Key Words	Histone deacetylase 10; Colorectal cancer; Tumor microenvironment; Immunotherapy resistance; P53-programmed death ligand 1 ‎axis
Core Tip	Histone deacetylase 10 (HDAC10) plays a multifaceted role in colorectal cancer by modulating immune evasion, ‎chemoresistance, and transcriptional regulation. Its suppression influences CD8⁺ T cell activation, ‎enhances p53 expression, and reduces programmed death ligand 1 levels, suggesting critical involvement in tumor-‎immune interactions. Selective HDAC10 inhibition, unlike pan-HDAC blockade, may offer ‎targeted therapeutic benefit, particularly in microsatellite-stable tumors. Further in vivo studies and ‎mechanistic dissection of HDAC10-p53-programmed death ligand 1 signaling are essential to harness its full potential ‎in reshaping the tumor microenvironment and improving immunotherapy outcomes.‎
Citation	Afzal A, Muanprasat C, Khawar MB. Prognostic role of histone deacetylase 10 in colorectal cancer: Strengths and ‎gaps. World J Gastroenterol 2025; In press

Received	2025-07-14 03:07
Peer-Review Started	2025-07-14 03:07
To Make the First Decision
Return for Revision	2025-07-18 08:04
Revised	2025-07-29 16:12
Second Decision	2025-09-16 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-16 03:27
Articles in Press	2025-09-16 03:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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