Publication Name	World Journal of Transplantation
Manuscript ID	111959
Country	United Kingdom

Category	Transplantation
Manuscript Type	Retrospective Cohort Study
Article Title	Outcomes of basiliximab vs alemtuzumab induction in kidney allograft recipients with matched immunological Profiles: A retrospective cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Chukwuma A Chukwu, Philip A Kalra, Marcus Lowe, Kay Poulton, Titus Augustine and Anirudh Rao
Funding Agency and Grant Number
Corresponding Author	Chukwuma A Chukwu, Consultant, PhD, Department of Nephrology, Liverpool University Hospitals NHS Foundation Trust, Mount Vernon Street, Liverpool L7 8YE, Mersey Side, United Kingdom. chukwuma.chukwu@rlbuht.nhs.uk
Key Words	Kidney transplantation; Immunosuppression induction; Alemtuzumab; Basiliximab; Graft outcomes
Core Tip	This retrospective cohort study compared real-world outcomes of alemtuzumab and basiliximab induction in kidney transplant recipients from two tertiary centers in North-West England, one routinely using alemtuzumab and the other exclusively basiliximab. Using propensity score matching to reduce confounding, we evaluated graft function, graft and patient survival, acute rejection, infection, and other long-term complications. Alemtuzumab induction was found to be associated with lower estimated glomerular filtration rate, and higher risks of cytomegalovirus and BK viremia, post-transplant malignancy, and death-censored graft loss compared with basiliximab. These findings emphasize the need for individualized selection of induction therapy, balancing the potent immunosuppressive effects of alemtuzumab against its potential for adverse outcomes, and support tailored approaches based on recipient risk profile and center-specific experience.
Citation	Chukwu CA, Kalra PA, Lowe M, Poulton K, Augustine T, Rao A. Outcomes of basiliximab vs alemtuzumab induction in kidney allograft recipients with matched immunological Profiles: A retrospective cohort study. World J Transplant 2025; In press

Received	2025-07-15 23:19
Peer-Review Started	2025-07-15 23:20
First Decision by Editorial Office Director	2025-08-05 08:57
Return for Revision	2025-08-05 08:57
Revised	2025-10-09 17:26
Publication Fee Transferred	2025-10-13 16:49
Second Decision by Editor	2025-12-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-09 07:51
Articles in Press	2025-12-09 07:51
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ISSN	2220-3230 (online)
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