Publication Name	World Journal of Hepatology
Manuscript ID	111962
Country	Germany

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Performance of three clinical scores for steatosis and steatohepatitis and thei interaction with metabolic syndrome in obese individuals
Manuscript Source	Invited Manuscript
All Author List	Giovani Schulte Farina, Bárbara Brambilla, Emanuelle Mendonça Pandolfo, Laura Kalil Nader Lazzaretti, Stéfano Mateus Schio Kuiava, Ana Maria Graciolli, Vitória Maria Kriger, Carlos Henrique Dal Bem Fistarol, Augusto Cardoso Sgarioni, Henrique Prataviera Giovanardi, Aline Caldart Tregnago, Floriano Riva, Cassiano da Silva Scholze, Daniel Cecconi Agostini, Bruno Dellamea, Arturo Tamayo, Tiago Lemos Cerqueira, Jonathan Soldera and Ben Min-Woo Illigens
Funding Agency and Grant Number
Corresponding Author	Giovani Schulte Farina, MD, Master's Program in Clinical Research, Dresden International University, Freiberger Str. 37, Dresden 01067, Saxony, Germany. farina.giovanimd@gmail.com
Key Words	Metabolically-dysfunction-associated steatotic liver disease; Liver steatosis; Steatohepatitis; Obesity; Clinical scores
Core Tip	This study evaluated and optimized the diagnostic performance of three clinical scores— Non-alcoholic fatty liver disease Liver Fat Score, Hepatic Steatosis Index, and Fatty Liver Index—for detecting steatosis and steatohepatitis in obese individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Using liver biopsy as a reference, we showed that standard thresholds performed poorly, but accuracy improved with optimized cut-offs. Metabolic syndrome status did not affect score performance significantly, suggesting that these tools can be applied across the MASLD metabolic spectrum. Our findings provide practical insights into improving non-invasive diagnosis in high-risk populations, where early detection is essential but challenging.
Citation	Farina GS, Brambilla B, Pandolfo EM, Lazzaretti LKN, Kuiava SMS, Graciolli AM, Kriger VM, Fistarol CHDB, Sgarioni AC, Giovanardi HP, Tregnago AC, Riva F, Scholze CDS, Agostini DC, Dellamea B, Tamayo A, Cerqueira TL, Soldera J, Illigens BMW. Performance of three clinical scores for steatosis and steatohepatitis and their interaction with metabolic syndrome in obese individuals. World J Hepatol 2025; In press

Received	2025-07-15 11:04
Peer-Review Started	2025-07-15 11:04
First Decision by Editorial Office Director	2025-07-18 07:39
Return for Revision	2025-07-18 07:39
Revised	2025-08-01 02:44
Publication Fee Transferred
Second Decision by Editor	2025-12-18 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-18 07:29
Articles in Press	2025-12-18 07:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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