Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	111973
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Factors influencing analysis of the efficacy of probiotics combined with enteral nutrition in postoperative patients with colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Zhang, Jie Wu, Yuan Yuan, Yong-Sheng Huang and Hua Han
Funding Agency and Grant Number	Funding Agency Grant Number Zunyi Science and Technology Plan Project Zunshi Kehe HZ Zi (2023) No. 49
Corresponding Author	Hua Han, Department of Clinical Nutrition, the First People's Hospital of Zunyi (the Third Affiliated Hospital of Zunyi Medical University), No. 98 Fenghuang Road, Huichuan District, Zunyi 563000, Guizhou Province, China. hanhuahao2009@163.com
Key Words	Colorectal cancer; Probiotics; Enteral nutrition; Postoperative recovery; Gut microbiota; Immune markers
Core Tip	This retrospective study identifies key predictors influencing the efficacy of probiotics combined with enteral nutrition in 511 postoperative colorectal cancer patients. Younger age, higher protein intake, balanced gut microbiota (elevated Bifidobacterium, reduced Fusobacterium nucleatum), and improved immune markers independently correlated with better outcomes. These findings highlight modifiable factors—nutritional optimization and microbiota modulation—for enhancing recovery. Multivariate analysis confirmed age, tumor node metastasis stage, protein intake, and microbial composition as significant prognostic indicators.
Citation	Zhang Y, Wu J, Yuan Y, Huang YS, Han H. Factors influencing analysis of the efficacy of probiotics combined with enteral nutrition in postoperative patients with colorectal cancer. World J Gastrointest Surg 2025; In press

Received	2025-07-15 09:32
Peer-Review Started	2025-07-15 09:32
To Make the First Decision
Return for Revision	2025-08-06 08:38
Revised	2025-08-13 06:30
Second Decision	2025-09-17 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-17 03:51
Articles in Press	2025-09-17 03:51
Publication Fee Transferred	2025-08-18 06:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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