Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	111975
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Long-term survival after multimodality treatment of metastatic mixed adenoneuroendocrine carcinoma of colon: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Jun Pan, Rong-Sheng Zhang, Ying Chen, Xiao-Hui Cao, Zhi-Hui Yang, Lu Lu, Yi-Tian Chen and Xiao-Yuan Chu
Funding Agency and Grant Number
Corresponding Author	Xiao-Yuan Chu, MD, Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, No. 305 Zhongshan East Road, Nanjing 210008, Jiangsu Province, China. chuxiaoyuan0@163.com
Key Words	Mixed adenoneuroendocrine carcinoma; Liver metastasis; Ascending colon; Surgery; Chemotherapy; Case report
Core Tip	Mixed adenoneuroendocrine carcinoma (MANEC) is a rare type of malignant tumor, but there is no standard treatment protocol. This article reviews a case of a patient diagnosed with liver metastasis from ascending colon MANEC. The patient experienced multiple recurrent liver metastases. Through a multidisciplinary treatment approach including chemotherapy, surgical resection, and radiofrequency ablation, the patient achieved complete response and a long-term survival of ten years. The comprehensive treatment approach has shown encouraging results for MANEC and is worthy of further study.
Citation	Pan J, Zhang RS, Chen Y, Cao XH, Yang ZH, Lu L, Chen YT, Chu XY. Long-term survival after multimodality treatment of metastatic mixed adenoneuroendocrine carcinoma of colon: A case report. World J Gastrointest Surg 2025; In press

Received	2025-07-16 05:23
Peer-Review Started	2025-07-16 05:23
To Make the First Decision
Return for Revision	2025-07-19 01:43
Revised	2025-08-04 03:35
Second Decision	2025-08-15 02:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 11:24
Articles in Press	2025-08-15 11:24
Publication Fee Transferred	2025-08-06 06:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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