Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	111977
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	L-arginine-induced chronic pancreatitis in mice: Evaluating effects of pirfenidone and simvastatin
Manuscript Source	Invited Manuscript
All Author List	Rajiv Mehta, Archi Patel, Bhavin Vyas, Bhargavi Desai, Dhvani Adhvaryu, Prakash Sojitra and Simple Bhuptani
Funding Agency and Grant Number
Corresponding Author	Rajiv Mehta, Department of Gastroenterology, SIDS Hospital and Research Centre, Surat Institute of Digestive Sciences, Khatodra-bamroli road, near Shell Petrol pump, Surat 395002, Gujarat, India. rmgastro@yahoo.com
Key Words	Pirfenidone; Simvastatin; Chronic pancreatitis; L-arginine; Oxidative stress
Core Tip	Combination therapy with pirfenidone and simvastatin significantly attenuated inflammation, fibrosis, and oxidative stress in an L-arginine-induced mouse model of chronic pancreatitis. The synergistic action led to reduced tumor necrosis factor-alpha, transforming growth factor-beta 1, and lipid peroxidation levels, along with a preservation of pancreatic tissue architecture. The combination therapy also enhanced antioxidant defense as evidenced by increased glutathione peroxidase 1 activity, indicating mitigation of oxidative damage. These findings highlighted a promising strategy targeting multiple pathological pathways, namely inflammatory, fibrotic, and oxidative stress mechanisms, and supported further evaluation of this combination in translational and clinical studies for chronic pancreatitis.
Citation	Mehta R, Patel A, Vyas B, Desai B, Adhvaryu D, Sojitra P, Bhuptani S. L-arginine-induced chronic pancreatitis in mice: Evaluating effects of pirfenidone and simvastatin. World J Gastrointest Pharmacol Ther 2025; In press

Received	2025-07-15 11:20
Peer-Review Started	2025-07-15 11:20
To Make the First Decision
Return for Revision	2025-07-28 08:28
Revised	2025-08-13 07:48
Second Decision	2025-11-13 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 07:10
Articles in Press	2025-11-13 07:10
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ISSN	2150-5349 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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