Publication Name	World Journal of Clinical Cases
Manuscript ID	112021
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Discontinuation of advanced therapy in inflammatory bowel disease: Updated evidence, guidelines, and personalized decision-making one year later
Manuscript Source	Unsolicited Manuscript
All Author List	Salvatore Greco, Michele Campigotto and Nicolò Fabbri
Funding Agency and Grant Number
Corresponding Author	Salvatore Greco, MD, Department of Internal Medicine, Ospedale del Delta, AUSL Ferrara, Via valle Oppio 2, Lagosanto 44023, Ferrara, Italy. grcsvt@unife.it
Key Words	Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease; Biologic therapy; Discontinuation of therapy; Personalized medicine
Core Tip	Discontinuation of advanced therapies in inflammatory bowel diseases remains a high-stakes decision, with relapse, immunogenicity, and long-term complications all weighing heavily. Despite updated international guidelines and emerging therapies, a personalized, closely monitored approach remains essential to ensure safe and effective treatment de-escalation in both Crohn’s disease and ulcerative colitis.
Citation	Greco S, Campigotto M, Fabbri N. Discontinuation of advanced therapy in inflammatory bowel disease: Updated evidence, guidelines, and personalized decision-making one year later. World J Clin Cases 2025; In press

Received	2025-07-16 02:34
Peer-Review Started	2025-07-16 02:34
First Decision by Editorial Office Director	2025-10-13 09:04
Return for Revision	2025-10-13 14:01
Revised	2025-10-13 16:07
Publication Fee Transferred
Second Decision by Editor	2025-12-15 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-16 01:58
Articles in Press	2025-12-16 01:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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