Publication Name	World Journal of Clinical Oncology
Manuscript ID	112039
Country	United States

Category	Oncology
Manuscript Type	Clinical Trials Study
Article Title	Acute exercise-induced catecholaminergic responses after 16 weeks of community-based exercise training in early-stage breast cancer survivors
Manuscript Source	Invited Manuscript
All Author List	Jeb F Struder, Aiden J Chauntry, Lauren C Bates-Fraser, Elizabeth P Harrell, Jordan T Lee, Chad W Wagoner, Stephanie A Sullivan, David B Bartlett, Hyman B Muss, Brian C Jensen, Claudio L Battaglini and Erik D Hanson
Funding Agency and Grant Number	Funding Agency Grant Number the Breast Cancer Research Foundation of New York, NY BCRF-17-112 the National Cancer Institute’s National Research Service Award sponsored by the Lineberger Comprehensive Cancer Center at the University of North Carolina T32 CA116339 the National Heart, Lung, and Blood Institute of the National Institutes of Health R01HL162805 and R01HL157187
Corresponding Author	Erik D Hanson, Associate Professor, PhD, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Campus Box #8700, Chapel Hill, NC 27599, United States. edhanson@email.unc.edu
Key Words	Autonomic function; Breast neoplasms; Cancer survivorship; Cardiovascular stress response; Catecholamines; Exercise therapy; Sympathetic nervous system
Core Tip	Exercise training partially restored immune cell responses previously diminished within untrained breast cancer survivors (BCS) immediately post-exercise. Epinephrine and norepinephrine are exercise-responsive and regulate immune cell function, suggesting a role in this training-induced restoration. Acute exercise induces similar BCS catecholaminergic attenuation; however, it is unclear whether this is sustained post-training. In this study, we aimed to compare acute exercise-induced catecholaminergic responses between BCS and non-cancer controls (CON) before and after a training intervention. BCS and CON presented with similar exercise-induced catecholaminergic responses regardless of training, suggesting the immune cell revival previously observed may be regulated by alternative mechanisms.
Citation	Struder JF, Chauntry AJ, Bates-Fraser LC, Harrell EP, Lee JT, Wagoner CW, Sullivan SA, Bartlett DB, Muss HB, Jensen BC, Battaglini CL, Hanson ED. Acute exercise-induced catecholaminergic responses after 16 weeks of community-based exercise training in early-stage breast cancer survivors. World J Clin Oncol 2025; In press

Received	2025-07-16 01:36
Peer-Review Started	2025-07-16 01:36
First Decision by Editorial Office Director	2025-07-28 08:29
Return for Revision	2025-07-28 08:29
Revised	2025-08-19 20:54
Publication Fee Transferred
Second Decision by Editor	2025-12-08 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-08 07:47
Articles in Press	2025-12-08 07:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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