Publication Name	World Journal of Nephrology
Manuscript ID	112066
Country	China

Category	Research & Experimental Medicine
Manuscript Type	Basic Study
Article Title	Gut microbiota-derived trimethylamine N-oxide exacerbates diabetic nephropathy by promoting renal fibrosis
Manuscript Source	Invited Manuscript
All Author List	Yue-Juan Song, Bo Yang, Qiang-Sheng Feng, Fei-Fei Ma, Bang Xing, Xi-Liang Bin and Xiao-Qin Ha
Funding Agency and Grant Number	Funding Agency Grant Number Chinese People’s Liberation Army No. 2021yxky056
Corresponding Author	Xiao-Qin Ha, Chief Physician, Clinical Laboratory, The 940th Hospital of Joint Logistics Support Force of People’s Liberation Army, No. 333 Binhe Middle Road, Lanzhou 730050, Gansu Province, China. songyuejuan410@163.com
Key Words	Diabetic nephropathy; Gut microbiota; Trimethylamine N-oxide; Kidney injury; Fibrosis
Core Tip	Diabetic nephropathy (DN) is characterized by significant renal dysfunction and gut microbiota dysbiosis, which enhances the microbiota’s capacity to produce trimethylamine N-oxide (TMAO). In Zucker diabetic fatty rats, elevated TMAO levels were associated with aggravated renal injury, fibrosis, and upregulated P-smad3 expression. Fecal microbiota transplantation from DN rats further increased TMAO production, confirming TMAO as a key microbiota-derived mediator in DN progression.
Citation	Song YJ, Yang B, Feng QS, Ma FF, Xing B, Bin XL, Ha XQ. Gut microbiota-derived trimethylamine N-oxide exacerbates diabetic nephropathy by promoting renal fibrosis. World J Nephrol 2025; In press

Received	2025-07-17 03:33
Peer-Review Started	2025-07-17 03:34
To Make the First Decision
Return for Revision	2025-08-08 08:58
Revised	2025-08-18 13:36
Second Decision	2025-11-20 23:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-21 01:12
Articles in Press	2025-11-21 01:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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