Publication Name	World Journal of Psychiatry
Manuscript ID	112073
Country	Japan

Category	Psychiatry
Manuscript Type	Editorial
Article Title	Unlocking the silent signals: Motor kinematics as a new frontier in early detection of mild cognitive impairment
Manuscript Source	Invited Manuscript
All Author List	Takahiko Nagamine
Funding Agency and Grant Number
Corresponding Author	Takahiko Nagamine, MD, PhD, Professor, Psychiatric Internal Medicine, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu 7470066, Yamaguchi, Japan. anagamine@yahoo.co.jp
Key Words	Mild cognitive impairment; Early detection; Motor kinematics; Gait analysis; Handwriting analysis; Digital biomarkers; Machine learning
Core Tip	This study proposes a paradigm shift in mild cognitive impairment screening, moving from subjective cognitive tests to objective, quantifiable measures of gait and handwriting kinematics. This novel approach uses readily observable behaviors and non-invasive technology (like digital pens) to circumvent barriers of traditional neuropsychological assessments, such as language dependency and cultural bias. By measuring motor kinematics, which capture the real-world effect of cognitive-motor changes, the method offers ecological validity and reflects functional status, distinguishing it from biomarkers focused only on pathology. The integration of gross and fine motor abilities provides a scalable and accessible foundation for early, proactive mild cognitive impairment detection, paving the way for better intervention.
Citation	Nagamine T. Unlocking the silent signals: Motor kinematics as a new frontier in early detection of mild cognitive impairment. World J Psychiatry 2025; In press

Received	2025-07-17 04:06
Peer-Review Started	2025-07-17 04:06
To Make the First Decision
Return for Revision	2025-09-04 06:43
Revised	2025-09-05 00:11
Second Decision	2025-11-12 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-12 09:02
Articles in Press	2025-11-12 09:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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