Publication Name	World Journal of Stem Cells
Manuscript ID	112100
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Human umbilical cord mesenchymal stem cells alleviated diarrhea-type irritable bowel syndrome by improving intestinal function
Manuscript Source	Unsolicited Manuscript
All Author List	He-Ming Zhang, Yu Zhang, Guang-Jie Luo, An-Xing Zhang, Ruo-Chang Li, Hai-Bo Dong, Teng-Yun Dong, Peng-Cheng Yu, Ying An and Yan Li
Funding Agency and Grant Number
Corresponding Author	Yan Li, PhD, Professor, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming 650032, Yunnan Province, China. hepatocellular@sina.com
Key Words	Diarrhea-type irritable bowel syndrome; Human umbilical cord mesenchymal stem cells; Gut flora; Intestinal barrier function; Intestinal inflammation
Core Tip	Irritable bowel syndrome (IBS) is a complex bowel disorder marked by recurrent abdominal pain and irregular stools. It is a persistent condition and greatly affects patients’ quality of life. We used three different dosages of human umbilical cord mesenchymal stem cells to treat diarrheal IBS using a rat model. We performed a series of experimental tests and data analyses and found that human umbilical cord mesenchymal stem cells could reduce the expression of inflammatory factors, improve that of intestinal barrier functional proteins, and maintain the abundance and diversity of intestinal flora to restore the intestinal function of diarrheal IBS by colonizing the colon tissue.
Citation	Zhang HM, Zhang Y, Luo GJ, Zhang AX, Li RC, Dong HB, Dong TY, Yu PC, An Y, Li Y. Human umbilical cord mesenchymal stem cells alleviated diarrhea-type irritable bowel syndrome by improving intestinal function. World J Stem Cells 2025; In press

Received	2025-07-18 03:36
Peer-Review Started	2025-07-18 03:36
To Make the First Decision
Return for Revision	2025-08-06 10:13
Revised	2025-08-19 08:33
Second Decision	2025-10-30 22:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-06 09:27
Articles in Press	2025-11-06 09:27
Publication Fee Transferred	2025-08-21 05:36
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Typeset the Manuscript

ISSN	1948-0210 (online)
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