Publication Name	World Journal of Hepatology
Manuscript ID	112104
Country	China

Category	Medicine, General & Internal
Manuscript Type	Letter to the Editor
Article Title	Predicting steroid response in acute alcohol-associated hepatitis: Beyond biomarkers of alcohol consumption
Manuscript Source	Invited Manuscript
All Author List	Jin-Wei Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82170406 National Natural Science Foundation of China No. 81970238
Corresponding Author	Jin-Wei Zhang, PhD, Professor, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, No. 345 Lingling Road, Shanghai 200032, China. jinweizhang@sioc.ac.cn
Key Words	Acute alcohol-associated hepatitis; Steroid therapy; Treatment response; Biomarkers; Liver transplantation; Phosphatidylethanol
Core Tip	This manuscript offers a thorough analysis of Sabatose et al's study exploring predictors of steroid response in acute alcohol-associated hepatitis (AAH). The study examines the role of alcohol consumption biomarkers (such as phosphatidylethanol) and clinical factors, revealing that age, pre-steroid albumin, and bilirubin levels-rather than alcohol-related markers-are key predictors of non-response. The identification of poorer outcomes in non-responders, coupled with insights into limitations and future research directions, provides valuable guidance for clinical decision-making and the development of improved strategies for AAH management.
Citation	Zhang JW. Predicting steroid response in acute alcohol-associated hepatitis: Beyond biomarkers of alcohol consumption. World J Hepatol 2025; In press

Received	2025-07-17 12:24
Peer-Review Started	2025-07-17 12:25
To Make the First Decision
Return for Revision	2025-08-28 09:27
Revised	2025-08-30 08:30
Second Decision	2025-09-15 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-17 10:34
Articles in Press	2025-09-17 10:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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