Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	112124
Country	China

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Concerns regarding lipid metabolism, immune regulation, and methodology in a study on esophageal cancer lymph node metastasis
Manuscript Source	Invited Manuscript
All Author List	Xu Cui and Zheng Liang
Funding Agency and Grant Number	Funding Agency Grant Number Fujian Provincial Science and Technology Innovation Joint Fund Project 2024Y9555 Fujian Provincial Natural Science Foundation Project 2024J011124
Corresponding Author	Xu Cui, PhD, Department of Pediatric Surgery, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou 350001, Fujian Province, China. 16802937@qq.com
Key Words	Lipid metabolism; Esophageal cancer; Lymph node metastasis; Low-density lipoprotein; Immune regulation
Core Tip	This letter raises concerns about a study investigating lipid metabolism and lymph node metastasis in esophageal cancer, focusing on three key issues: Insufficient data on lipid parameters [especially low-density lipoprotein (LDL) distribution] in the patient cohort, unclear rationale for selecting LDL-related genes and excluding other lipid metabolism pathways in gene screening, and a lack of direct evidence supporting the proposed LDL-B lymphocyte regulatory axis. It emphasizes the complexity of lipid-immune crosstalk in tumors and suggests future studies address these points to strengthen conclusions on lipid-immune regulation in esophageal cancer.
Citation	Cui X, Liang Z. Concerns regarding lipid metabolism, immune regulation, and methodology in a study on esophageal cancer lymph node metastasis. World J Gastrointest Surg 2025; In press

Received	2025-07-18 03:51
Peer-Review Started	2025-07-18 03:51
To Make the First Decision
Return for Revision	2025-08-06 10:09
Revised	2025-08-08 13:12
Second Decision	2025-09-17 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-17 03:35
Articles in Press	2025-09-17 03:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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