Publication Name	World Journal of Gastroenterology
Manuscript ID	112132
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Association of FADS2 polymorphism rs174538 with fatty acid metabolism and disease severity in Japanese patients with Crohn's disease
Manuscript Source	Unsolicited Manuscript
All Author List	Hideyuki Matsuzawa, Zensho Ito, Kan Uchiyama, Yutaro Motoi, Yuichiro Ohtaki, Yuko Iwashita, Shizuka Suzuki, Tatsuya Nakada, Shigeo Koido, Kana Kojima, Kota Murohashi, Masayuki Saruta, Toshifumi Ohkusa and Takahiro Kubota
Funding Agency and Grant Number
Corresponding Author	Hideyuki Matsuzawa, Doctorate Student, Faculty of Pharmacy, Department of Biopharmaceutics, Niigata University of Pharmacy and Medical and Life Sciences, 265-1 Higashijima, Akiha-Ku, Niigata 956-8603, Japan. hideyuki.m.0918@gmail.com
Key Words	Crohn’s disease; FADS2 gene; rs174538; FADS1 gene; Crohn’s disease activity index
Core Tip	Erythrocyte membrane fatty acid composition ratios in Japanese Crohn's disease (CD) patients are distinctive. Analysis was performed to determine effects on FADS2 genetic polymorphisms by serum and erythrocyte membrane fatty acid composition ratios, shown by delta 6 and delta 5 desaturases (D6D and D5D, respectively), and also disease activities. The FADS2 gene with the rs174538 mutation affected D6D and D5D activities, with a greater effect on D5D. However, for disease activity, wild-type rs174538 was positively correlated with D6D activity. These results indicate that confirmation of the rs174538 mutation can be used to predict disease severity in CD cases.
Citation	Matsuzawa H, Ito Z, Uchiyama K, Motoi Y, Ohtaki Y, Iwashita Y, Suzuki S, Nakada T, Koido S, Kojima K, Murohashi K, Saruta M, Ohkusa T, Kubota T. Association of FADS2 polymorphism rs174538 with fatty acid metabolism and disease severity in Japanese patients with Crohn's disease. World J Gastroenterol 2025; In press

Received	2025-07-31 04:01
Peer-Review Started	2025-07-31 04:01
To Make the First Decision
Return for Revision	2025-08-25 07:53
Revised	2025-09-02 02:48
Second Decision	2025-11-28 03:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-28 08:04
Articles in Press	2025-11-28 08:04
Publication Fee Transferred	2025-09-03 04:45
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ISSN	1007-9327 (print) and 2219-2840 (online)
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