| Category |
Otorhinolaryngology |
| Manuscript Type |
Basic Study |
| Article Title |
Expression patterns and clinical implications of chaperonin subunit 3 mRNA and protein in laryngeal squamous cell carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bin-Yu Mo, Jia-Ying Wen, Guo-Qiang Chen, Jing-Wen Ling, Han He, Zi-Li Qin, Fang-Yun Tian, Qi Li, Bin Li, Jian-Di Li, Rong-Quan He, Di-Yuan Qin, Zong-Yu Li, Gang Chen, Chao-Hua Mo, Chang Chen, Shi-Hua Yin and Li Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82160213 and No. U22A2022 |
| Guangxi Natural Science Foundation |
No. 2023GXNSFAA026029 |
| Guangxi Natural Science Foundation |
No. 2024GXNSFBA010059 and No.2024GXNSFAA010079 |
|
| Corresponding Author |
Shi-Hua Yin, Professor, Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Guangxi Medical University, No. 166 East Daxue Road, Xixiangtang District, Nanning 530007, Guangxi Zhuang Autonomous Region, China. shihuayin@gxmu.edu.cn |
| Key Words |
Laryngeal squamous cell carcinoma; Chaperonin-containing TCP1 subunit 3; Gene expression; Summary receiver operating characteristic; Area under the curve |
| Core Tip |
In this study, single-cell RNA-seq and functional clustered regularly interspaced short palindromic repeats screening demonstrated the overexpression of chaperonin-containing TCP1 subunit 3 in laryngeal squamous cell carcinoma, thereby showing its role in promoting cell viability. Gene set enrichment analysis indicated that chaperonin-containing TCP1 subunit 3 is involved in extracellular matrix receptor interaction and cell cycle pathways, highlighting its potential as a biomarker and therapeutic target for laryngeal squamous cell carcinoma. |
| Citation |
Mo BY, Wen JY, Chen GQ, Ling JW, He H, Qin ZL, Tian FY, Li Q, Li B, Li JD, He RQ, Qin DY, Li ZY, Chen G, Mo CH, Chen C, Yin SH, Yang L. Expression patterns and clinical implications of chaperonin subunit 3 mRNA and protein in laryngeal squamous cell carcinoma. World J Clin Oncol 2025; In press |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
