Publication Name	World Journal of Cardiology
Manuscript ID	112189
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Semaglutide in patients with obesity and heart failure with preserved ejection fraction: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Maneeth Mylavarapu, Ogechukwu Obi, Yozahandy Abarca, Husna Fatima, Prarath Roshni, Noor Ul Huda, Yuliya Lysak, Asad Gandapur, Samantha Contreras Vazquez, Muhammad Areeb Siddiqui and Adetola Mowo-Wale
Funding Agency and Grant Number
Corresponding Author	Maneeth Mylavarapu, Department of Cardiology, Endeavor Health Cardiovascular Institute, 2100 Pfingsten Rd, Glenview, IL 60026, United States, Glenview, IL 60026, United States. dr.maneeth.mylavarapu@gmail.com
Key Words	Semaglutide; Heart failure with preserved ejection fraction; Obesity; Weight-loss; GLP-1 receptor agonists; Meta-analysis
Core Tip	This meta-analysis demonstrates that semaglutide is effective in reducing weight and potentially lowering the risk of heart failure events in patients with obesity and heart failure with preserved ejection fraction (HFpEF). This suggests semaglutide as a promising therapeutic option for managing obesity-related HFpEF, a condition with limited current treatment options. The findings showed statistically higher odds of 10% and 15% weight reduction, as well as lower odds of adjudicated heart failure events, in patients receiving semaglutide compared to those receiving placebo. Further large-scale trials are needed to confirm these benefits and explore long-term outcomes.
Citation	Mylavarapu M, Obi O, Abarca Y, Fatima H, Roshni P, Huda NU, Lysak Y, Gandapur A, Vazquez SC, Siddiqui MA, Mowo-wale A. Semaglutide in patients with obesity and heart failure with preserved ejection fraction: A systematic review and meta-analysis. World J Cardiol 2026; In press

Received	2025-07-21 01:53
Peer-Review Started	2025-07-21 01:53
First Decision by Editorial Office Director	2025-08-14 07:14
Return for Revision	2025-08-14 07:14
Revised	2025-11-06 18:45
Publication Fee Transferred
Second Decision by Editor	2026-01-19 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-19 04:06
Articles in Press	2026-01-19 04:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com